When you're selecting your best picks for your first and second round picks to target, it is all about minimizing risk. Also, you want to look for the most consistent of the bunch.
After that, there is a lot of great options. For instance, I recommend targeting Antonio Brown due to his ultimate Wide Receiver consistency. Another recommendation is both Alvin Kamara and Kareem Hunt for high usage up and comers. Also, pick Melvin Gordon and Deandre Hopkins for TD's.
In summary, make sure you select the right guys on your Draft Board. Indeed, you don't want to get caught trying to fill the void of a stud - first and second rounder.
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